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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1996-5-15
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pubmed:abstractText |
NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membranes obtained from 19 pools of two venous blood samples from female young (19-30 years) individuals and 18 pools from aged ones (66-107 years). The enzyme activities were not significantly changed in the two groups, but a decrease of sensitivity to the specific inhibitor, rotenone, occurred in a substantial number of aged individuals. The results are in agreement with the predictions of the mitochondrial theory of ageing and may be used to develop a sensitive biomarker of the ageing process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
380
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
176-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8603732-Adult,
pubmed-meshheading:8603732-Aged,
pubmed-meshheading:8603732-Aged, 80 and over,
pubmed-meshheading:8603732-Aging,
pubmed-meshheading:8603732-Biological Markers,
pubmed-meshheading:8603732-Blood Platelets,
pubmed-meshheading:8603732-Electron Transport Complex I,
pubmed-meshheading:8603732-Enzyme Inhibitors,
pubmed-meshheading:8603732-Female,
pubmed-meshheading:8603732-Humans,
pubmed-meshheading:8603732-Mitochondria,
pubmed-meshheading:8603732-NADH, NADPH Oxidoreductases,
pubmed-meshheading:8603732-Rotenone
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pubmed:year |
1996
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pubmed:articleTitle |
Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing.
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pubmed:affiliation |
Department of Biochemistry 'G. Morruzzi', University of Bologna, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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