Linked Life Data

8603425

Source:http://linkedlifedata.com/resource/pubmed/id/8603425

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-5-15
pubmed:abstractText
An orally administered soluble protein antigen, ovalbumin (OVA), enterocoated with an acid-resistant acrylic polymer, induced a strong humoral immune response in BDF1 mice, exhibiting Th2 cell phenotype, typified by increased OVA-specific IgA, IgG1, and IgE antibody responses. This antibody response was accompanied by OVA-specific T cell proliferation response and IL-4 cytokine production. Mice fed enterocoated OVA and administered anti-IL-4 mAb showed a shift of the immune response toward the Th1 cell phenotype as evidenced by increased IFN-gamma production and anti-OVA IgG2a isotype antibody response. Additionally, in mice fed OVA solution and simultaneously administered anti-IL-4, we saw a slight but significant expression of Th1 cell phenotype. In conclusion, our data indicate that the dominance of Th2 cell phenotype in oral immunity is strongly influenced by the production and presence of IL-4.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-8749
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
170-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Activation patterns of murine T cells after oral administration of an enterocoated soluble antigen.
pubmed:affiliation
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Ohio 45267-0524, USA.
pubmed:publicationType
Journal Article