Linked Life Data

8603005

Source:http://linkedlifedata.com/resource/pubmed/id/8603005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-5-15
pubmed:abstractText
Trisomy 12 and deletions or translocations of 13q14 are the commonest cytogenetic abnormalities in chronic lymphocytic leukaemia but rarely co-exist in the same patient. We describe eight patients from a series of > 400 patients with CLL in whom trisomy 12 and t or del 13 occur in the same clone. Using FISH we have identified clones with trisomy 12 alone, t or del 13q14 alone and both abnormalities, in each of the patients studied. This implies that neither trisomy 12 nor t or del 13q14 is the initiating event in leukaemogenesis, but does not exclude the possibility of a submicroscopic abnormality of 13q14 occurring as an early event.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-92
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia.
pubmed:affiliation
Department of Haematology, Royal Bournemouth Hospital.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't