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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6575
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pubmed:dateCreated |
1996-5-8
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pubmed:abstractText |
Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of phospholipase C delta 1 reveals a multidomain protein incorporating modules shared by many signalling proteins. The structure suggests a mechanism for membrane attachment and Ca2+-dependent hydrolysis of second-messenger precursors. The regulation and reversible membrane association of PI-PLC may serve as a model for understanding other multidomain enzymes involved in phospholipid signalling.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
380
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-602
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8602259-Amino Acid Sequence,
pubmed-meshheading:8602259-Animals,
pubmed-meshheading:8602259-Binding Sites,
pubmed-meshheading:8602259-Catalysis,
pubmed-meshheading:8602259-Cell Membrane,
pubmed-meshheading:8602259-Crystallography, X-Ray,
pubmed-meshheading:8602259-Humans,
pubmed-meshheading:8602259-Hydrolysis,
pubmed-meshheading:8602259-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:8602259-Isoenzymes,
pubmed-meshheading:8602259-Models, Molecular,
pubmed-meshheading:8602259-Molecular Conformation,
pubmed-meshheading:8602259-Molecular Sequence Data,
pubmed-meshheading:8602259-Phosphoinositide Phospholipase C,
pubmed-meshheading:8602259-Phospholipase C delta,
pubmed-meshheading:8602259-Phosphoric Diester Hydrolases,
pubmed-meshheading:8602259-Protein Binding,
pubmed-meshheading:8602259-Protein Conformation,
pubmed-meshheading:8602259-Rats,
pubmed-meshheading:8602259-Recombinant Proteins,
pubmed-meshheading:8602259-Second Messenger Systems,
pubmed-meshheading:8602259-Sequence Homology, Amino Acid
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pubmed:year |
1996
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pubmed:articleTitle |
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
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pubmed:affiliation |
Center for Protein Engineering, MRC Centre, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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