Linked Life Data

8601501

Source:http://linkedlifedata.com/resource/pubmed/id/8601501

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-5-6
pubmed:abstractText
A statistical method was developed for reconstructing the nucleotide or amino acid sequences of extinct ancestors, given the phylogeny and sequences of the extant species. A model of nucleotide or amino acid substitution was employed to analyze data of the present-day sequences, and maximum likelihood estimates of parameters such as branch lengths were used to compare the posterior probabilities of assignments of character states (nucleotides or amino acids) to interior nodes of the tree; the assignment having the highest probability was the best reconstruction at the site. The lysozyme c sequences of six mammals were analyzed by using the likelihood and parsimony methods. The new likelihood-based method was found to be superior to the parsimony method. The probability that the amino acids for all interior nodes at a site reconstructed by the new method are correct was calculated to be 0.91, 0.86, and 0.73 for all, variable, and parsimony-informative sites, respectively, whereas the corresponding probabilities for the parsimony method were 0.84, 0.76, and 0.51, respectively. The probability that an amino acid in an ancestral sequence is correctly reconstructed by the likelihood analysis ranged from 91.3 to 98.7% for the four ancestral sequences.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-1633570, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-1960739, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-2318301, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-2330057, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-3120013, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-7288891, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-7532788, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-7713447, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-7739387, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-7932785, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-8064867, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-8114118, http://linkedlifedata.com/resource/pubmed/commentcorrection/8601501-8277861
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1641-50
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A new method of inference of ancestral nucleotide and amino acid sequences.
pubmed:affiliation
Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA. ziheng@mws4.biol.berkeley.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.