Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-5-9
pubmed:abstractText
The rates of oxygen consumption in liver mitochondria of strain S rats (2-3- and 10-12-months-old) with inherited free radical hyperproduction during oxidation of three types of substrates (glutamate+maleate, succinate+rotenone and ascorbate+TMPD) as well as cytochrome a level in the respiratory chain are lowered in comparison with Wistar controls. In liver mitochondria of 10-12-months-old rats these changes are more pronounced and manifest themselves as decreased ADP/O, phosphorylation rates and F0F1-ATPase activity. The phosphorylation potential, ATP content and adenine nucleotide pool in rat liver are also reduced. The experimental results give a better insight into the pathogenetic mechanisms of morbid states (e.g., degenerative diseases) in human beings and shed additional light on the origin of short lifespan and premature in strain S rats.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0320-9725
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2045-52
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Oxidative phosphorylation activity, F0F1-ATPase and level of liver mitochondrial cytochromes in rats with congenitally increased ability for free radical formation].
pubmed:publicationType
Journal Article, English Abstract