Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-5-2
pubmed:abstractText
Bistratene A, a toxin isolated from the colonial ascidian Lissoclinum bistratum causes a decrease in mitotic index and retardation of lymphocyte proliferation kinetics when it is added at 48 h to 72-h human lymphocyte cultures. In the same cultures, the incidence of sister chromatid exchanges was not altered by this compound. We also observed an increase in the number of polyploid cells in the cultures, and alterations of the beta-tubulin organization by immunocytochemistry with an antibody against beta-tubulin. Bistratene A induces DNA damage in a dose-dependent fashion in leukocytes, as measured by the alkaline single cell gel electrophoresis assay. These results show that bistratene A interferes with microtubule assembly, is cytotoxic and cytostatic, and that it causes DNA damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
367
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-75
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:8600373-Acetamides, pubmed-meshheading:8600373-Actin Cytoskeleton, pubmed-meshheading:8600373-Animals, pubmed-meshheading:8600373-Cell Division, pubmed-meshheading:8600373-Cells, Cultured, pubmed-meshheading:8600373-DNA, pubmed-meshheading:8600373-DNA Damage, pubmed-meshheading:8600373-Demecolcine, pubmed-meshheading:8600373-Ethers, Cyclic, pubmed-meshheading:8600373-Humans, pubmed-meshheading:8600373-Lymphocytes, pubmed-meshheading:8600373-Marine Toxins, pubmed-meshheading:8600373-Microtubules, pubmed-meshheading:8600373-Phytohemagglutinins, pubmed-meshheading:8600373-Polyploidy, pubmed-meshheading:8600373-Pyrans, pubmed-meshheading:8600373-Sister Chromatid Exchange, pubmed-meshheading:8600373-Spiro Compounds, pubmed-meshheading:8600373-Tubulin, pubmed-meshheading:8600373-Urochordata
pubmed:year
1996
pubmed:articleTitle
Genotoxic effects of bistratene A on human lymphocytes.
pubmed:affiliation
Departamento de Genética y Toxicología Ambiental, Instituto de Investigaciones Biomedicas, Mexico.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't