Linked Life Data

8600139

Source:http://linkedlifedata.com/resource/pubmed/id/8600139

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-5-2
pubmed:abstractText
This paper presents an original experimental procedure designed to evaluate, by a two step in vivo/in vitro combination, the long-term biocompatibility of synthetic materials developed for clinical applications. The efficacy of the test is illustrated by the experimental results obtained with various materials currently used in medicine (Dacron, RCH) and also with three recently synthesized compounds. In the first step of the procedure, the sample was grafted for at least 5 months in the peritoneal cavity of mice, allowing the possible development of delayed sensitization. In the second step, this sensitization was detected by an in vitro test, the Lymphoblastic Transformation Test (LTT), adapted for this new purpose. On the basis of this experiment, the 5 polymers tested were classified into 2 groups: one group did not significantly differ from the control, and the other had a significantly higher incidence of sensitization. As these results were in agreement with the known biocompatibility of these polymers, they demonstrate the validity of the test to classify new polymers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9304
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1493-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Delayed in vitro immune response to long-term intraperitoneal polymer implant in mice.
pubmed:affiliation
Laboratoire d'Histologie Faculté de Médecine Saint-Antoine, Paris, France.
pubmed:publicationType
Journal Article