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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5255
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pubmed:dateCreated |
1996-4-25
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pubmed:abstractText |
Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this "priming" effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-hydroxy-2-N,N-dipropylaminotetrali...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ergolines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/SK&F 81297,
http://linkedlifedata.com/resource/pubmed/chemical/SK&F 82958,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1586-9
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:8599115-Animals,
pubmed-meshheading:8599115-Behavior, Addictive,
pubmed-meshheading:8599115-Behavior, Animal,
pubmed-meshheading:8599115-Benzazepines,
pubmed-meshheading:8599115-Caffeine,
pubmed-meshheading:8599115-Cocaine,
pubmed-meshheading:8599115-Dopamine Agonists,
pubmed-meshheading:8599115-Ergolines,
pubmed-meshheading:8599115-Male,
pubmed-meshheading:8599115-Motor Activity,
pubmed-meshheading:8599115-Quinpirole,
pubmed-meshheading:8599115-Rats,
pubmed-meshheading:8599115-Rats, Sprague-Dawley,
pubmed-meshheading:8599115-Receptors, Dopamine D1,
pubmed-meshheading:8599115-Receptors, Dopamine D2,
pubmed-meshheading:8599115-Recurrence,
pubmed-meshheading:8599115-Reinforcement (Psychology),
pubmed-meshheading:8599115-Substance-Related Disorders,
pubmed-meshheading:8599115-Tetrahydronaphthalenes
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pubmed:year |
1996
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pubmed:articleTitle |
Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists.
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pubmed:affiliation |
Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, 06508, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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