| pubmed-article:8599114 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0042760 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0040223 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0025515 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:8599114 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8599114 | pubmed:issue | 5255 | lld:pubmed |
| pubmed-article:8599114 | pubmed:dateCreated | 1996-4-25 | lld:pubmed |
| pubmed-article:8599114 | pubmed:abstractText | A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t 1/2 = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t 1/2 = 0.24 days). The estimated average total HIV-1 production was 10.3 x 10(9) virions per day, which is substantially greater than previous minimum estimates. The results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time--defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles--is 2.6 days. These findings on viral dynamics provide not only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to guide the development of treatment strategies. | lld:pubmed |
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| pubmed-article:8599114 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8599114 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8599114 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8599114 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8599114 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8599114 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8599114 | pubmed:author | pubmed-author:LeonardJ MJM | lld:pubmed |
| pubmed-article:8599114 | pubmed:author | pubmed-author:PerelsonA SAS | lld:pubmed |
| pubmed-article:8599114 | pubmed:author | pubmed-author:MarkowitzMM | lld:pubmed |
| pubmed-article:8599114 | pubmed:author | pubmed-author:CuqPP | lld:pubmed |
| pubmed-article:8599114 | pubmed:author | pubmed-author:NeumannA UAU | lld:pubmed |
| pubmed-article:8599114 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8599114 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8599114 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8599114 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8599114 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8599114 | pubmed:pagination | 1582-6 | lld:pubmed |
| pubmed-article:8599114 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8599114 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8599114 | pubmed:articleTitle | HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. | lld:pubmed |
| pubmed-article:8599114 | pubmed:affiliation | Theoretical Division, Los Alamos National Laboratory, NM 87545, USA. | lld:pubmed |
| pubmed-article:8599114 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8599114 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8599114 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8599114 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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