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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5255
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pubmed:dateCreated |
1996-4-25
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pubmed:abstractText |
A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-1 protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t 1/2 = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t 1/2 = 0.24 days). The estimated average total HIV-1 production was 10.3 x 10(9) virions per day, which is substantially greater than previous minimum estimates. The results also suggest that the minimum duration of the HIV-1 life cycle in vivo is 1.2 days on average, and that the average HIV-1 generation time--defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles--is 2.6 days. These findings on viral dynamics provide not only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to guide the development of treatment strategies.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Ritonavir,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Valine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1582-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8599114-Antiviral Agents,
pubmed-meshheading:8599114-CD4 Lymphocyte Count,
pubmed-meshheading:8599114-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8599114-Cell Survival,
pubmed-meshheading:8599114-HIV Infections,
pubmed-meshheading:8599114-HIV Protease Inhibitors,
pubmed-meshheading:8599114-HIV-1,
pubmed-meshheading:8599114-Half-Life,
pubmed-meshheading:8599114-Humans,
pubmed-meshheading:8599114-Kinetics,
pubmed-meshheading:8599114-Models, Biological,
pubmed-meshheading:8599114-RNA, Viral,
pubmed-meshheading:8599114-Regression Analysis,
pubmed-meshheading:8599114-Ritonavir,
pubmed-meshheading:8599114-Thiazoles,
pubmed-meshheading:8599114-Valine,
pubmed-meshheading:8599114-Viremia,
pubmed-meshheading:8599114-Virion,
pubmed-meshheading:8599114-Virus Replication
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pubmed:year |
1996
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pubmed:articleTitle |
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.
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pubmed:affiliation |
Theoretical Division, Los Alamos National Laboratory, NM 87545, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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