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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-4-24
|
| pubmed:abstractText |
Platelet interactions with the injured vessel wall may contribute significantly to the early and late failures of many cardiovascular interventions; the adhesive protein von Willebrand factor (vWF) is thought to play an important role. Previously, we demonstrated that heparin interfered with platelet/vWF hemostatic mechanisms by binding to vWF within the proteins's domain responsible for binding the platelet vWF receptor, glycoprotein Ib. The purpose of the present study was to develop and refine heparins with greater potency to inhibit platelet/vWF interactions.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0009-7322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
992-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8598091-Anticoagulants,
pubmed-meshheading:8598091-Blood Platelets,
pubmed-meshheading:8598091-Chromatography, Affinity,
pubmed-meshheading:8598091-Heparin,
pubmed-meshheading:8598091-Humans,
pubmed-meshheading:8598091-Partial Thromboplastin Time,
pubmed-meshheading:8598091-Platelet Aggregation,
pubmed-meshheading:8598091-Prothrombin Time,
pubmed-meshheading:8598091-von Willebrand Factor
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Heparins designed to specifically inhibit platelet interactions with von Willebrand factor.
|
| pubmed:affiliation |
Division of Vascular Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|