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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-4-24
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pubmed:abstractText |
Numerous studies have demonstrated the ability of angiotensin II (Ang II) receptor antagonists and angiotensin-converting enzyme (ACE) inhibitors to inhibit intimal hyperplasia after balloon dilation of noncoronary arteries in small-animal models, suggesting an important role for Ang II in the response to injury. Although ACE inhibitors have not been similarly effective in nonhuman coronary models or in human restenosis trials, questions remain regarding the efficacy ACE inhibitors against tissue ACE and the contributions of ACE-independent pathways of Ang II generation. Unlike ACE inhibitors, Ang II receptor antagonists have the potential to inhibit responses to Ang II independent of its biosynthetic origin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0009-7322
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pubmed:author |
pubmed-author:AckerW RWR,
pubmed-author:ChangR SRS,
pubmed-author:DragM DMD,
pubmed-author:FujitaTT,
pubmed-author:GreenleeW JWJ,
pubmed-author:HoldenD FDF,
pubmed-author:HuckleW RWR,
pubmed-author:JohnsonR GRGJr,
pubmed-author:KimDD,
pubmed-author:MantloN BNB,
pubmed-author:McFallR CRC,
pubmed-author:OndeykaD LDL,
pubmed-author:PowersMM,
pubmed-author:ReillyC FCF,
pubmed-author:SchwartzR SRS,
pubmed-author:StabilitoI III
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1009-19
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8598064-Angiotensin II,
pubmed-meshheading:8598064-Angiotensin Receptor Antagonists,
pubmed-meshheading:8598064-Animals,
pubmed-meshheading:8598064-Coronary Disease,
pubmed-meshheading:8598064-Coronary Vessels,
pubmed-meshheading:8598064-Disease Models, Animal,
pubmed-meshheading:8598064-Imidazoles,
pubmed-meshheading:8598064-Rats,
pubmed-meshheading:8598064-Recurrence,
pubmed-meshheading:8598064-Sulfonamides,
pubmed-meshheading:8598064-Swine,
pubmed-meshheading:8598064-Tetrazoles
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pubmed:year |
1996
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pubmed:articleTitle |
Effects of subtype-selective and balanced angiotensin II receptor antagonists in a porcine coronary artery model of vascular restenosis.
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pubmed:affiliation |
Department of Pharmacology, Merck Research Laboratories, West Point, PA 19486, USA.
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pubmed:publicationType |
Journal Article
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