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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
5
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pubmed:dateCreated |
1996-4-15
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94822,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94823,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94824,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94825,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94826,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94827,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94828,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94829,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94830,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94831,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94832,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94833,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94834,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94835,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94836,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94837,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94838,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94839,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94840,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94841,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94842,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94843,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94844,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94845,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94846,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94847,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94848,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94849,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94850,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X94851
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pubmed:abstractText |
The TCR V beta element is pivotal for superantigen recognition; however, not all T cells bearing a particular V beta element respond to an individual superantigen. Recent evidence has indicated that the TCR V alpha element also contributes to recognition of superantigen/MHC class II complexes. To determine whether the TCR beta-chain junctional regions influence recognition of a superantigen encoded by mouse mammary tumor virus (MMTV) proviral integrant Mtv-1, we have analyzed these regions in T cells that have survived superantigen-mediated negative selection in B10.BR-Mtv-1 mice. Our data indicate: 1) no TCR J beta skewing, 2) no difference in the length of the third complementarity-determining region (CDR3), and 3) no outstanding structural features that are shared among the junctional regions of the V beta 3+ T cells that escape thymic clonal elimination in superantigen-expressing mice. Several possible models for TCR engagement of viral superantigen/MHC class II complexes are discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1865-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8596038-Amino Acid Sequence,
pubmed-meshheading:8596038-Animals,
pubmed-meshheading:8596038-Antigen Presentation,
pubmed-meshheading:8596038-Base Composition,
pubmed-meshheading:8596038-Base Sequence,
pubmed-meshheading:8596038-Clonal Deletion,
pubmed-meshheading:8596038-Hybridomas,
pubmed-meshheading:8596038-Mammary Tumor Virus, Mouse,
pubmed-meshheading:8596038-Mice,
pubmed-meshheading:8596038-Mice, Inbred C3H,
pubmed-meshheading:8596038-Mice, Inbred C57BL,
pubmed-meshheading:8596038-Molecular Sequence Data,
pubmed-meshheading:8596038-Multigene Family,
pubmed-meshheading:8596038-Proviruses,
pubmed-meshheading:8596038-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8596038-Structure-Activity Relationship,
pubmed-meshheading:8596038-Superantigens,
pubmed-meshheading:8596038-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
Receptors on T cells escaping superantigen-mediated deletion lack special beta-chain junctional region structural characteristics.
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pubmed:affiliation |
Department of Immunology, University of Washington, Seattle, WA 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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