Linked Life Data

8595847

Source:http://linkedlifedata.com/resource/pubmed/id/8595847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-4-16
pubmed:abstractText
In the oral environment, gingival lymphocytes are involved in maintaining the local immune defense of periodontal tissues. The corrosion rates of copper-based dental casting alloys and the accumulation of corrosion products in host gingiva raise concerns about the effects of these corrosion products on immune responses in the oral cavity. The aim of this study ws to investigate the hypothesis that immune function may be altered by copper dental alloy corrosion products. In vitro cell culture studies were used to analyze the effects of three copper-based dental alloys on a T-cell and B-cell line and their secretion of soluble immune mediators (IL-2) and effectors (IgG), respectively. Results of this study revealed that corrosion products released from copper alloys in 24 h have the ability to reduce cellular viability, alter proliferation, and modulate the production of soluble immune mediators. These results support the hypothesis that copper dental ally corrosion products may alter immune responses and thereby contribute to a variety of dental pathological conditions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0109-5641
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-90
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of copper-based dental casting alloys on two lymphocyte cell lines and the secretion of interleukin 2 and IgG.
pubmed:affiliation
Department of Biomedical Engineering, University of Alabama at Birmingham, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.