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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1996-4-18
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pubmed:abstractText |
The serotonin (5-HT) agonist m-chlorophenylpiperazine (mCPP) is commonly used as a neuroendocrine challenge agent in humans, and it is well accepted that its mechanism of action involves direct stimulation of postsynaptic 5-HT receptors. In the present work, we demonstrate that mCPP also displays appreciable affinity (IC50 = 230 nM) for 5-HT transporters labeled by [125I]3 beta-(4-iodophenyl)tropan-2 beta-carboxylic acid methyl ester ([125I]RTI-55) in human occipital cortex. These data agree with reports that show mCPP increases extracellular 5-HT in rat brain via a mechanism involving 5-HT transporters. Our results indicate that mCPP may exhibit a presynaptic 5-HT action in man, and studies utilizing mCPP to assess 5-HT receptor sensitivity should be interpreted with caution.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(3-chlorophenyl)piperazine,
http://linkedlifedata.com/resource/pubmed/chemical/Biogenic Monoamines,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Fenfluramine,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2150-2
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8595191-Adult,
pubmed-meshheading:8595191-Binding, Competitive,
pubmed-meshheading:8595191-Binding Sites,
pubmed-meshheading:8595191-Biogenic Monoamines,
pubmed-meshheading:8595191-Brain,
pubmed-meshheading:8595191-Carrier Proteins,
pubmed-meshheading:8595191-Dopamine,
pubmed-meshheading:8595191-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:8595191-Fenfluramine,
pubmed-meshheading:8595191-Humans,
pubmed-meshheading:8595191-Male,
pubmed-meshheading:8595191-Membrane Glycoproteins,
pubmed-meshheading:8595191-Membrane Transport Proteins,
pubmed-meshheading:8595191-Middle Aged,
pubmed-meshheading:8595191-Nerve Tissue Proteins,
pubmed-meshheading:8595191-Norepinephrine,
pubmed-meshheading:8595191-Piperazines,
pubmed-meshheading:8595191-Serotonin,
pubmed-meshheading:8595191-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:8595191-Serotonin Receptor Agonists
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pubmed:year |
1995
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pubmed:articleTitle |
The serotonin agonist m-chlorophenylpiperazine (mCPP) binds to serotonin transporter sites in human brain.
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pubmed:affiliation |
Clinical Psychopharmacology Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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