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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1996-4-11
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pubmed:abstractText |
In order to study the impact of serotonin depletion on gene expression of the serotonin transporter (5-HTt) we measured 5-HTt mRNA levels by Northern blot in rats treated with p-chlorophenylalanine methyl ester (PCPA) for 10 days. Six rats received PCPA i.p. only, and another 6 rats receiving 0.9% NaCl served as controls. An additional group of 6 rats received both PCPA i.p. and imipramine, 5 mg/kg/day by osmotic minipumps. 5-HTt mRNA levels decreased to 81.1% (P = 0.05) and 76.0% (P = 0.05) of the control level for PCPA treated animals without and with concomitant imipramine treatment, respectively. The average level of the PCPA treated groups was 78.6% (P = 0.03). The isolated effect of 21 days of imipramine treatment was a 5-HTt mRNA level of 89.4%, which was not significantly different from the control level. In conclusion, 5-HTt gene expression is suppressed in the serotonin depleted state. A decreased synaptic reuptake of 5-HT may be interpreted as a compensatory mechanism aiming at preserving adequate synaptic 5-HT levels in a generally deficient state.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-chlorophenylalanine methyl ester,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fenclonine,
http://linkedlifedata.com/resource/pubmed/chemical/Imipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
697
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-3
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8593584-Animals,
pubmed-meshheading:8593584-Blotting, Northern,
pubmed-meshheading:8593584-Carrier Proteins,
pubmed-meshheading:8593584-Fenclonine,
pubmed-meshheading:8593584-Gene Expression,
pubmed-meshheading:8593584-Imipramine,
pubmed-meshheading:8593584-Male,
pubmed-meshheading:8593584-Membrane Glycoproteins,
pubmed-meshheading:8593584-Membrane Transport Proteins,
pubmed-meshheading:8593584-Mesencephalon,
pubmed-meshheading:8593584-Nerve Tissue Proteins,
pubmed-meshheading:8593584-RNA, Messenger,
pubmed-meshheading:8593584-Raphe Nuclei,
pubmed-meshheading:8593584-Rats,
pubmed-meshheading:8593584-Rats, Wistar,
pubmed-meshheading:8593584-Reference Values,
pubmed-meshheading:8593584-Serotonin,
pubmed-meshheading:8593584-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:8593584-Time Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Serotonin depletion decreases serotonin transporter mRNA levels in rat brain.
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pubmed:affiliation |
Institute for Basic Research in Psychiatry, Psychiatric University Hospital, Risskov, Denmark.
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pubmed:publicationType |
Journal Article
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