Linked Life Data

8592482

Source:http://linkedlifedata.com/resource/pubmed/id/8592482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-4-3
pubmed:abstractText
The direct effect of sorbitol and L-xylose on net intestinal calcium transport was compared to that of lactose, by determining unidirectional steady state calcium fluxes in segments of rat ileum in vitro under short-circuited conditions. The iso-molar addition of either 100 mM sorbitol, L-xylose, or lactose in mucosal buffer fluid increased the absorptive flux of Ca from mucosa to serosa to a similar extent and thus reversed ileal net Ca transport from net secretion to a zero net movement. The three substances decreased tissue conductance and reversed tissue polarity. At 200 mM, sorbitol induced a stimulation of net Ca transport due to an enhancement of absorptive Ca flux but in addition due to a decrease of secretory Ca flux from serosa to mucosa. The presence of 1 mM N-ethylmaleimide abolished the effects of sorbitol on ileal Ca flux. In conclusion, the present result shows that sorbitol, L-xylose, and lactose increase net Ca absorption to a comparable extent, in the absence of electrochemical or osmotic gradients. Such an absence of specificity suggests a stimulation of transcellular Ca transport related to the decrease of Na concentration in mucosal solution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-0392
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Stimulating effects of sorbitol and L-xylose on rat ileal Ca transport in vitro.
pubmed:affiliation
INSERM U90, Hôpital Necker, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study