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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1996-4-3
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pubmed:abstractText |
Methods for improving the fertilizing potential of the spermatozoa in human in-vitro fertilization (IVF) include the stimulation of sperm function in vitro. Metabolic stimulation in vitro has become a major issue in assisted reproductive technology (ART). Here, we review our research on the unselective use of pentoxifylline in IVF for male-factor infertility. Data from our controlled studies indicate that an indiscriminate use of 3.6 mM pentoxifylline, alone or in combination with 3.0 mM 2-deoxyadenosine, is not beneficial in enhancing fertilization rates in zero and poor in-vitro fertilizers or in the presence of antisperm antibodies. An assessment of the effects of pentoxifylline on sperm function prior to IVF may ensure a more rational use of these compounds in selected cases undergoing ART. At present, however, controlled studies in subgroups of patients selected by functional testing are still lacking.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0268-1161
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
72-9
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:8592044-Animals,
pubmed-meshheading:8592044-Embryonic and Fetal Development,
pubmed-meshheading:8592044-Fertilization in Vitro,
pubmed-meshheading:8592044-Humans,
pubmed-meshheading:8592044-Infertility, Male,
pubmed-meshheading:8592044-Male,
pubmed-meshheading:8592044-Mice,
pubmed-meshheading:8592044-Pentoxifylline,
pubmed-meshheading:8592044-Reproductive Techniques
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pubmed:year |
1995
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pubmed:articleTitle |
Use of pentoxifylline in assisted reproductive technology.
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pubmed:affiliation |
Centre for Reproductive Medicine, University Hospital, Dutch-speaking Brussels Free University (Vrije Universiteit Brussel), Belgium.
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pubmed:publicationType |
Journal Article,
Review
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