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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-4-3
|
| pubmed:abstractText |
Five Acinetobacter baumannii strains of various phenotypes were selected on the basis of the results of a national survey in France in 1991. beta-Lactamases in Acinetobacter isolates were characterized by isoelectrofocusing. We carried out a 24 h time-kill study to assess the bactericidal effect of antibiotic alone or in combination against A. baumannii strains. The initial inoculum was 10(6) cfu/mL. Antibiotics were tested at MIC x 2 when an antibiotic was tested alone and at the MIC for each combination including ticarcillin, piperacillin, ceftazidime or imipenem with or without amikacin or netilmicin and/or beta-lactamase inhibitors. Concentration of inhibitors were: 2 mg/L for clavulanic acid, 4 mg/L for tazobactam and 8 mg/L for sulbactam. Sulbactam and tazobactam showed an intrinsic in-vitro activity against strains susceptible to ticarcillin. A complete killing at 24 h was observed when beta-lactams were combined with amikacin in comparison with antibiotics alone. Synergy was lost when the strain presented a low resistance level to beta-lactams or aminoglycosides except for ticarcillin. Combinations of sulbactam with ticarcillin showed the best bactericidal activity against strains multiresistant to beta-lactams.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0305-7453
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
619-29
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8591936-Acinetobacter,
pubmed-meshheading:8591936-Acinetobacter Infections,
pubmed-meshheading:8591936-Aminoglycosides,
pubmed-meshheading:8591936-Anti-Bacterial Agents,
pubmed-meshheading:8591936-Drug Interactions,
pubmed-meshheading:8591936-Drug Synergism,
pubmed-meshheading:8591936-Drug Therapy, Combination,
pubmed-meshheading:8591936-Humans,
pubmed-meshheading:8591936-Microbial Sensitivity Tests,
pubmed-meshheading:8591936-Phenotype,
pubmed-meshheading:8591936-beta-Lactamases,
pubmed-meshheading:8591936-beta-Lactams
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Bactericidal in-vitro activity of beta-lactams and beta-lactamase inhibitors, alone or associated, against clinical strains of Acinetobacter baumannii: effect of combination with aminoglycosides.
|
| pubmed:affiliation |
Department of microbiology, Bichat-Claude Bernard University, Paris, France.
|
| pubmed:publicationType |
Journal Article
|