Linked Life Data

8590819

Source:http://linkedlifedata.com/resource/pubmed/id/8590819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-4-3
pubmed:abstractText
The cytokine interleukin-1 (IL-1) is released by a variety of cells in response to infection or injury. IL-1 produces several neuroendocrine and behavioral effects, including a suppression of reproductive functions and goal-directed behaviors. The present study examined the effect of IL-1 on sexual behavior in male and female rats. The following behavioral tests were employed: preference for a sexually appropriate partner, proceptive (soliciting) behavior, the lordosis quotient (sexual receptivity), and mating performance. Peripheral (ip) IL-1 beta, 2 or 10 micrograms/kg, injected 2 h before testing, significantly suppressed proceptive behavior and sexual receptivity in intact, normally cycling females. In ovariectomized rats treated with ovarian hormones, IL-1 beta (2 or 10 micrograms/kg) significantly decreased the preference for a sexually active male partner and suppressed proceptive behavior and sexual receptivity. These effects were evident 2, but not 4 or 6, h after IL-1 beta administration. Intracerebroventricular administration of IL-1 beta (10 ng/rat) also suppressed the preference for a male partner and proceptive behavior in normally cycling females. Similar doses of IL-1 beta had no suppressive effect on any aspect of male sexual behavior, and the highest dose even increased the preference for a receptive female partner. In contrast to the gender-specific effects on sexual behavior, the suppressive effects of IL-1 beta on activity in the open-field test were comparable in male and female rats. The inhibition of female sexual behavior by IL-1 may be adaptive, in that it prevents conception while the animal is sick, thus reducing the risk of spontaneous abortion or abnormal development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0889-1591
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Interleukin-1 inhibits sexual behavior in female but not in male rats.
pubmed:affiliation
Department of Psychology, Hebrew University of Jerusalem, Mount Scopus, Israel.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't