| pubmed-article:8590454 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8590454 | lifeskim:mentions | umls-concept:C0027763 | lld:lifeskim |
| pubmed-article:8590454 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:8590454 | lifeskim:mentions | umls-concept:C0003577 | lld:lifeskim |
| pubmed-article:8590454 | lifeskim:mentions | umls-concept:C0205753 | lld:lifeskim |
| pubmed-article:8590454 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:8590454 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:8590454 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8590454 | pubmed:dateCreated | 1996-3-25 | lld:pubmed |
| pubmed-article:8590454 | pubmed:abstractText | 1. We have used biochemical, immunocytochemical, and electrophysiological techniques to evaluate the role of opioid peptides in the central nervous system of the marine mollusc, Aplysia californica. 2. Binding studies using 3H-D-Ala2, met-enkephalinamide (3H-DAMA) showed a single class of high-affinity binding sites with a Kd of 1.3 nM and a binding density of 45 pmol/g. 3. HPLC extracts of ganglia revealed multiple peaks with immunoreactivity for either leu (LEU-IR)- or met-enkephalin (MET-IR), but the amounts were not uniformly distributed in all ganglia. 4. LEU-IR and MET-IR neurons were demonstrated immunocytochemically in all ganglia, but MET-IR neurons were more frequent and were concentrated in pedal and pleural ganglia. While absorption control studies abolished MET-IR, LEU-IR was only partially abolished in the neuropil. 5. In electrophysiological studies, both depolarizing and hyperpolarizing responses were found to D-Ala2-leu-enkephalin (DALEU) and D-Ala2-met enkephalin (DAMET) on some and different neurons. 6. HPLC fractions from regions with retention times corresponding to authentic leu- or met-enkephalin showed physiologic responses similar to those of DALEU and DAMET, respectively. 7. These studies suggest that a variety of endogeneous opioid peptides play physiologically important roles in the nervous system of Aplysia, including but not necessarily limited to leu- and met-enkephalin. | lld:pubmed |
| pubmed-article:8590454 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8590454 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8590454 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8590454 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8590454 | pubmed:issn | 0272-4340 | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:CarpenterD... | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:LeungMM | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:RózsaK SKS | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:SalánkiJJ | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:ElekesKK | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:StefanoGG | lld:pubmed |
| pubmed-article:8590454 | pubmed:author | pubmed-author:KemenesGG | lld:pubmed |
| pubmed-article:8590454 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8590454 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:8590454 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8590454 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8590454 | pubmed:pagination | 239-56 | lld:pubmed |
| pubmed-article:8590454 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
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| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
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| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
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| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:meshHeading | pubmed-meshheading:8590454-... | lld:pubmed |
| pubmed-article:8590454 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8590454 | pubmed:articleTitle | Opioid peptides in the nervous system of Aplysia: a combined biochemical, immunocytochemical, and electrophysiological study. | lld:pubmed |
| pubmed-article:8590454 | pubmed:affiliation | Wadsworth Center for Laboratories and Research, New York State Department of Health and School of Public Health, Albany 12201, USA. | lld:pubmed |
| pubmed-article:8590454 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8590454 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8590454 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8590454 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8590454 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8590454 | lld:pubmed |
