| pubmed-article:8587372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C0026820 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C1282822 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C0226001 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8587372 | lifeskim:mentions | umls-concept:C0678568 | lld:lifeskim |
| pubmed-article:8587372 | pubmed:dateCreated | 1996-3-28 | lld:pubmed |
| pubmed-article:8587372 | pubmed:abstractText | The pathogenesis of the prolonged cold-induced vasospasm of Raynaud's disease (RD) is unknown. Cooling has been shown to decrease the sensitivity of cutaneous rabbit ear arteries to endothelin-1 (ET-1), perhaps by increasing the availability of nitric oxide (NO). If the endothelium in RD lacks this NO-mediated inhibitory function during cooling, increased production and enhanced constriction to ET-1 could cause vasospasm. This study examined the effect of cooling on the contractile response to ET-1 in human microvessels. Small arteries were dissected from biopsy specimens of human fat and were cannulated in a small vessel arteriograph. Cumulative concentration-response curves to ET-1 (10(-12) to 3 x 10(-7) M) were obtained in vessels at 37 degrees C (n = 8) and 24 degrees C (n = 7). Cooling to 24 degrees C resulted in an eightfold decrease in sensitivity to ET-1 (EC50 6.6 +/- 2.5 x 10(-10) M at 37 degrees C vs. 5.5 +/- 2.5 x 10(-9) M at 24 degrees C; p < 0.05, unpaired t test). The Emax was not significantly different at 37 degrees C and 24 degrees C (114 +/- 9 at 37 degrees C vs. 138 +/- 14 at 24 degrees C; p = 0.18). These results suggest that cooling decreases the sensitivity of human microvessels to ET-1. Further investigation is needed to establish the mechanism of this effect, including studies in vessels obtained from patients with RD. | lld:pubmed |
| pubmed-article:8587372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8587372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587372 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8587372 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8587372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8587372 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:8587372 | pubmed:author | pubmed-author:SmithP JPJ | lld:pubmed |
| pubmed-article:8587372 | pubmed:author | pubmed-author:WebbD JDJ | lld:pubmed |
| pubmed-article:8587372 | pubmed:author | pubmed-author:McQueenD SDS | lld:pubmed |
| pubmed-article:8587372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8587372 | pubmed:volume | 26 Suppl 3 | lld:pubmed |
| pubmed-article:8587372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8587372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8587372 | pubmed:pagination | S230-2 | lld:pubmed |
| pubmed-article:8587372 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:meshHeading | pubmed-meshheading:8587372-... | lld:pubmed |
| pubmed-article:8587372 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8587372 | pubmed:articleTitle | The effect of cooling on the contractile response to endothelin-1 in small arteries from humans. | lld:pubmed |
| pubmed-article:8587372 | pubmed:affiliation | Department of Pharmacology, University of Edinburgh, Scotland. | lld:pubmed |
| pubmed-article:8587372 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8587372 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8587372 | lld:pubmed |
