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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1996-3-28
|
| pubmed:abstractText |
The pathogenesis of the prolonged cold-induced vasospasm of Raynaud's disease (RD) is unknown. Cooling has been shown to decrease the sensitivity of cutaneous rabbit ear arteries to endothelin-1 (ET-1), perhaps by increasing the availability of nitric oxide (NO). If the endothelium in RD lacks this NO-mediated inhibitory function during cooling, increased production and enhanced constriction to ET-1 could cause vasospasm. This study examined the effect of cooling on the contractile response to ET-1 in human microvessels. Small arteries were dissected from biopsy specimens of human fat and were cannulated in a small vessel arteriograph. Cumulative concentration-response curves to ET-1 (10(-12) to 3 x 10(-7) M) were obtained in vessels at 37 degrees C (n = 8) and 24 degrees C (n = 7). Cooling to 24 degrees C resulted in an eightfold decrease in sensitivity to ET-1 (EC50 6.6 +/- 2.5 x 10(-10) M at 37 degrees C vs. 5.5 +/- 2.5 x 10(-9) M at 24 degrees C; p < 0.05, unpaired t test). The Emax was not significantly different at 37 degrees C and 24 degrees C (114 +/- 9 at 37 degrees C vs. 138 +/- 14 at 24 degrees C; p = 0.18). These results suggest that cooling decreases the sensitivity of human microvessels to ET-1. Further investigation is needed to establish the mechanism of this effect, including studies in vessels obtained from patients with RD.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26 Suppl 3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S230-2
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8587372-Aged,
pubmed-meshheading:8587372-Arteries,
pubmed-meshheading:8587372-Cold Temperature,
pubmed-meshheading:8587372-Dose-Response Relationship, Drug,
pubmed-meshheading:8587372-Endothelins,
pubmed-meshheading:8587372-Female,
pubmed-meshheading:8587372-Humans,
pubmed-meshheading:8587372-Male,
pubmed-meshheading:8587372-Middle Aged,
pubmed-meshheading:8587372-Vasoconstriction
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
The effect of cooling on the contractile response to endothelin-1 in small arteries from humans.
|
| pubmed:affiliation |
Department of Pharmacology, University of Edinburgh, Scotland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|