Linked Life Data

8587252

Source:http://linkedlifedata.com/resource/pubmed/id/8587252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-3-27
pubmed:abstractText
In 1991, Dubach et al clearly demonstrated an increased risk of renal morbidity and mortality after phenacetin abuse in middle aged working women. We investigated the renal effects of the abuse of several kinds of analgesics in abusers of different sex and age categories. A cohort of 200 active analgesic abusers (age range 21 to 86 years) and 200 matched controls was followed for seven years (1984 to 1992). Subjects were visited at home once a year for a short interview and a medical examination. Renal function showed a significant decrease over time in controls as well as in abusers (P < 0.001). The decrease was, however, significantly more pronounced in abusers (P < 0.001). The development of a decreased renal function was observed in 12 abusers and 2 controls resulting in a relative risk of 6.1 (95% CI: 1.4 to 25.9). Subjects showing a decreased renal function underwent a diagnostic investigation. Using validated diagnostic criteria, analgesic nephropathy could be established in 6 out of the 10 abusers who had a diagnostic workup, in the absence of any other form of renal disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0085-2538
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1912-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
A long-term prospective controlled study of analgesic abuse in Belgium.
pubmed:affiliation
Department of Nephrology-Hypertension, University of Antwerp, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't