Linked Life Data

8587122

Source:http://linkedlifedata.com/resource/pubmed/id/8587122

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-3-28
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/D11382, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/J02070, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L09548, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L14680, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L16462, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L22472, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L22473, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L26545, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L26546, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L31532, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M13994, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10101, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10597, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z23110, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z23115
pubmed:abstractText
The nature of the bcl-2 family of proto-oncogenes was analyzed by sequence alignment, secondary structure prediction, and phylogenetic techniques. Phylogenies were inferred from both the nucleic acid and amino acid sequences of the human, murine, rat, and chicken sequences for BCL-2 and BCL-X, human MCL1, murine A1, the nematode Caenorhabditis elegans and Caenorhabditis briggsiae ced-9 proteins, and the sequences BHRF1 from Epstein-Barr and LMW5-HL from African swine fever viruses. Both sequence alignment and secondary structure prediction techniques supported the conservation of both the overall secondary structure and the carboxy-terminal transmembrane domain in all members of the family. All the treeing methods employed (distance matrix, maximum likelihood, and parsimony) supported a tree in which the proapoptotic proteins BCL-2 and BCL-X represent the most recent additions to the group. All the trees also indicated that the viral proteins BHRF1 and LMW-HL arose from a common ancestor, an ancestor they shared in common with the pro-apoptotic control protein BAX, indicating that this function of BAX evolved only recently. The most ancient branches are represented by the nematode ced-9 protein and by the control genes MCL1 and A1, which in the treeing methods employed represent separate lineages within the most ancient grouping. These results demonstrate the evolution of a highly conserved family of developmental control genes from nematode to man--genes that encode proteins essential for normal development but which are highly conserved in terms of predicted structure and possible cellular localization. The evolutionary analysis also indicates that the family may be even larger than originally predicted and that other members are waiting to be discovered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-2844
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
775-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Molecular evolution and secondary structural conservation in the B-cell lymphoma leukemia 2 (bcl-2) family of proto-oncogene products.
pubmed:affiliation
Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't