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pubmed-article:8586661pubmed:abstractTextCell-to-cell channels are often seen clustered at cell-cell contacts into the so-called gap junction plaques. The mechanism of this clustering is unknown. We show that the clustering of cell-to-cell channels composed of connexin43 is induced by elevation of cyclic AMP. The cAMP-induced clustering is enhanced by inhibition of glycosylation and abolished by disruption of microfilaments. Channel clustering thus seems to be regulated by cAMP and glycosylation and to involve microfilaments.lld:pubmed
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pubmed-article:8586661pubmed:articleTitleClustering of Cx43 cell-to-cell channels into gap junction plaques: regulation by cAMP and microfilaments.lld:pubmed
pubmed-article:8586661pubmed:affiliationDepartment of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101, USA.lld:pubmed
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