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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1996-3-25
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pubmed:abstractText |
Cell-to-cell channels are often seen clustered at cell-cell contacts into the so-called gap junction plaques. The mechanism of this clustering is unknown. We show that the clustering of cell-to-cell channels composed of connexin43 is induced by elevation of cyclic AMP. The cAMP-induced clustering is enhanced by inhibition of glycosylation and abolished by disruption of microfilaments. Channel clustering thus seems to be regulated by cAMP and glycosylation and to involve microfilaments.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9533
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108 ( Pt 11)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3501-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8586661-Actin Cytoskeleton,
pubmed-meshheading:8586661-Animals,
pubmed-meshheading:8586661-Carcinoma, Hepatocellular,
pubmed-meshheading:8586661-Cell Communication,
pubmed-meshheading:8586661-Connexin 43,
pubmed-meshheading:8586661-Cyclic AMP,
pubmed-meshheading:8586661-Cytochalasins,
pubmed-meshheading:8586661-Endoplasmic Reticulum,
pubmed-meshheading:8586661-Forskolin,
pubmed-meshheading:8586661-Gap Junctions,
pubmed-meshheading:8586661-Glycosylation,
pubmed-meshheading:8586661-Golgi Apparatus,
pubmed-meshheading:8586661-Proteins,
pubmed-meshheading:8586661-Rats,
pubmed-meshheading:8586661-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Clustering of Cx43 cell-to-cell channels into gap junction plaques: regulation by cAMP and microfilaments.
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pubmed:affiliation |
Department of Physiology and Biophysics, University of Miami School of Medicine, Florida 33101, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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