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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-3-25
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87692,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87693,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87694,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87695,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87696,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87697,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87698,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87699,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87700,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87701,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87702,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87703,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87704,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87705,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87706,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87707,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87708,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87709,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87710,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87711,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87712,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87713,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87714,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87715,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87716,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87717,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87718,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87719,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87720,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X87721
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pubmed:abstractText |
We have mapped a region of high loss of heterozygosity in breast cancer to a 2-cM interval between the loci D1S430 and D1S465 on chromosome 1p31.1. This region shows allelic imbalance in around 60% of breast tumors. As part of a strategy to clone the target gene(s) within this interval, we have generated a yeast artificial chromosome contig spanning over 7 Mb. YACs from the CEPH and Zeneca (formerly ICI) libraries have been obtained by screening with PCR-based STSs from the region for both previously identified loci and newly isolated STSs. The YACs have been assembled into a contig by a combination of approaches, including analysis of their STS content, generation of new STSs from the ends of key YACs, and long-range restriction mapping. These YAC clones provide the basis for complete characterization of the region of high loss in breast cancer and for the ultimate identification of the target gene(s).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-43
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pubmed:dateRevised |
2006-4-6
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pubmed:meshHeading |
pubmed-meshheading:8586422-Base Sequence,
pubmed-meshheading:8586422-Breast Neoplasms,
pubmed-meshheading:8586422-Chromosome Deletion,
pubmed-meshheading:8586422-Chromosome Mapping,
pubmed-meshheading:8586422-Chromosomes, Artificial, Yeast,
pubmed-meshheading:8586422-Chromosomes, Human, Pair 1,
pubmed-meshheading:8586422-Cloning, Molecular,
pubmed-meshheading:8586422-DNA Primers,
pubmed-meshheading:8586422-Heterozygote,
pubmed-meshheading:8586422-Humans,
pubmed-meshheading:8586422-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8586422-Molecular Sequence Data,
pubmed-meshheading:8586422-Sequence Tagged Sites
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pubmed:year |
1995
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pubmed:articleTitle |
Identification and cloning in yeast artificial chromosomes of a region of elevated loss of heterozygosity on chromosome 1p31.1 in human breast cancer.
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pubmed:affiliation |
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, United Kingdom.
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pubmed:publicationType |
Journal Article
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