Linked Life Data

8586395

Source:http://linkedlifedata.com/resource/pubmed/id/8586395

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-3-25
pubmed:abstractText
The single channel features of inward rectifier potassium current (IK1) in primary cultured embryonic chick ventricular myocytes and the effect of culture time on it were studied by using cell-attached patch clamp technique. The results showed that inward current fluctuation could be recorded at membrane potential negative to the potassium equilibrium potential (EK) and [K+] o = [K+]i = 140 mmol/L. The single channel current-voltage (I-V) relation was linear. The slope conductance was 35 pS (1-3 day culture). But at membrane potential positive to the EK, strong inward rectification was evident. The analysis of open and close time distribution indicated that a close-close-open three state model was appropriate to describe the gating processes of IK1 channel. No significant effect of culture time was observed. The channel density and slope conductance of IK1 were 0.64, 0.76, 0.77 channels/microns and 35, 28, 37 pS corresponding to 1-3, 4-6, and 7-11 day culture period, respectively. This result could partially explain why action potential of cardiomyocytes did not change with culture time.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0257-7712
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Inward rectifier potassium current in cultured embryonic chick ventricular myocytes and effect of culture time].
pubmed:affiliation
Department of Physiology, Luzhou Medical College.
pubmed:publicationType
Journal Article, English Abstract