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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1996-3-20
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pubmed:abstractText |
Polyriboinosinic-polyribocytidylic acid [poly(IC.LC)] was evaluated for its prophylactic and therapeutic efficacies against respiratory influenza A virus infection in mice. Two doses of poly(IC.LC) (1 mg/kg of body weight per dose) administered intranasally within 12 days prior to infection with 10 50% lethal doses of mouse-adapted influenza A/PR/8 virus fully protected the mice against the infection. Determination of virus titers by hemagglutination and plaque assays showed more than a 2-log10 decrease in virus titers in lung homogenates of pretreated mice compared with those in the lungs of the nonpretreated group. Treatment of infected mice with poly(IC.LC) resulted in a modest (40%) survival rate. These results suggest that poly(IC.LC) provides a highly effective prophylaxis against respiratory influenza A virus infection in mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-109544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-202173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-2416883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-2416885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-4026264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-407312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-4078596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-408427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-6483899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-810520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8585749-8157277
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2574-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8585749-Administration, Intranasal,
pubmed-meshheading:8585749-Animals,
pubmed-meshheading:8585749-Antiviral Agents,
pubmed-meshheading:8585749-Carboxymethylcellulose Sodium,
pubmed-meshheading:8585749-Influenza A virus,
pubmed-meshheading:8585749-Injections, Intraperitoneal,
pubmed-meshheading:8585749-Interferon Inducers,
pubmed-meshheading:8585749-Interferons,
pubmed-meshheading:8585749-Lung,
pubmed-meshheading:8585749-Mice,
pubmed-meshheading:8585749-Orthomyxoviridae Infections,
pubmed-meshheading:8585749-Poly I-C,
pubmed-meshheading:8585749-Polylysine,
pubmed-meshheading:8585749-Viral Plaque Assay
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pubmed:year |
1995
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pubmed:articleTitle |
Prophylactic and therapeutic efficacies of poly(IC.LC) against respiratory influenza A virus infection in mice.
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pubmed:affiliation |
Medical Countermeasures Section, Defence Research Establishment Suffield, Ralston, Alberta, Canada.
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pubmed:publicationType |
Journal Article
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