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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1996-3-19
|
| pubmed:abstractText |
There are several pre- and postsynaptic sites where neuromuscular transmission failure (NTF) can occur, leading to peripheral muscle fatigue. Presynaptic sites of NTF include: axonal branch point conduction block; a failure of excitation-secretion coupling at the presynaptic terminal; reductions in quantal release of ACh; and reductions in quantal size. Postsynaptic sites of NTF include: cholinergic receptor desensitization; and reduced sarcolemmal excitability. Susceptibility to NTF increases with stimulation frequency and is most prevalent in fatigable fast-twitch motor units. In addition, susceptibility to NTF varies with age and with conditions of altered use.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0065-2598
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
384
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
83-100
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1995
|
| pubmed:articleTitle |
Fatigue at the neuromuscular junction. Branch point vs. presynaptic vs. postsynaptic mechanisms.
|
| pubmed:affiliation |
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
|