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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5251
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pubmed:dateCreated |
1996-3-21
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pubmed:abstractText |
The genetic background of T lymphocytes influences development of the T helper (TH) phenotype, resulting in either resistance or susceptibility of certain mouse strains to pathogens such as Leishmania major. With an in vitro model system, a difference in maintenance of responsiveness of T cells to interleukin-12 (IL-12) was detected between BALB/c and B10.D2 mice. Although naive T cells from both strains initially responded to IL-12, BALB/c T cells lost IL-12 responsiveness after stimulation with antigen in vitro, even when cocultured with B10.D2 T cells. Thus, susceptibility of BALB/c mice to infection with L. major may derive from the loss of the ability to generate IL-12-induced TH1 responses rather than from an IL-4-induced TH2 response.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
984-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8584935-Animals,
pubmed-meshheading:8584935-Cells, Cultured,
pubmed-meshheading:8584935-Coculture Techniques,
pubmed-meshheading:8584935-Genetic Predisposition to Disease,
pubmed-meshheading:8584935-Immunity, Innate,
pubmed-meshheading:8584935-Interferon-gamma,
pubmed-meshheading:8584935-Interleukin-12,
pubmed-meshheading:8584935-Interleukin-4,
pubmed-meshheading:8584935-Leishmania major,
pubmed-meshheading:8584935-Leishmaniasis, Cutaneous,
pubmed-meshheading:8584935-Lymphocyte Activation,
pubmed-meshheading:8584935-Mice,
pubmed-meshheading:8584935-Mice, Inbred BALB C,
pubmed-meshheading:8584935-Mice, Transgenic,
pubmed-meshheading:8584935-Phenotype,
pubmed-meshheading:8584935-Receptors, Interleukin-2,
pubmed-meshheading:8584935-Signal Transduction,
pubmed-meshheading:8584935-Th1 Cells,
pubmed-meshheading:8584935-Th2 Cells
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pubmed:year |
1996
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pubmed:articleTitle |
Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.
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pubmed:affiliation |
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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