Linked Life Data

8584559

Source:http://linkedlifedata.com/resource/pubmed/id/8584559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-3-19
pubmed:abstractText
This study was undertaken to evaluate the influence of acute doses of ethanol, chronic ethanol administration and the withdrawal syndrome on central dopaminergic neurotransmission in 700 rats. The ethanol effects were differentiated by their influence on D1 and D2 receptors using following dopaminergic ligands. SKF 38393 (2.5 mg/kg), SCH 23,390 (0.5 mg/kg), pimozide (1 mg/kg), PPHT (2 mg/kg). It was found that ethanol in a low single dose (1.0 g/kg p.o.) increased DA level in rats' brain. In chronic alcoholized rats SKF 38,393 increased the D1 receptor answer in biochemical and behavioural experiments. During the withdrawal period in rats D2 agonist PPHT reversed abstinence symptoms whereas other DA antagonists normalized only some parameters altered by ethanol removal from the diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
815-8
pubmed:dateRevised
2007-1-29
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The role of dopamine neurotransmission in ethanol dependence development and ethanol withdrawal in rats.
pubmed:affiliation
Department of Psychiatry, Pomeranian Medical Academy, Szczecin, Poland.
pubmed:publicationType
Journal Article