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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-3-19
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pubmed:abstractText |
Chronic liver disease is a well-recognised complication of cystic fibrosis. Recent reports suggest that its development is not determined by specific mutations within the cystic fibrosis gene; however, familial clustering of portal hypertension cases and inappropriate immune responses against liver membrane antigens demonstrated in children with cystic fibrosis and chronic liver disease suggest that other genetic loci may be relevant. As the major histocompatibility complex has an important immunoregulatory role, we have investigated for associations with this complex and chronic liver disease in cystic fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
532-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8583140-Adolescent,
pubmed-meshheading:8583140-Adult,
pubmed-meshheading:8583140-Case-Control Studies,
pubmed-meshheading:8583140-Child,
pubmed-meshheading:8583140-Child, Preschool,
pubmed-meshheading:8583140-Chronic Disease,
pubmed-meshheading:8583140-Complement C4,
pubmed-meshheading:8583140-Cystic Fibrosis,
pubmed-meshheading:8583140-Disease Progression,
pubmed-meshheading:8583140-Female,
pubmed-meshheading:8583140-Genes, MHC Class I,
pubmed-meshheading:8583140-Genes, MHC Class II,
pubmed-meshheading:8583140-Humans,
pubmed-meshheading:8583140-Infant,
pubmed-meshheading:8583140-Liver Diseases,
pubmed-meshheading:8583140-Male,
pubmed-meshheading:8583140-Phenotype,
pubmed-meshheading:8583140-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:8583140-Steroid 21-Hydroxylase
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pubmed:year |
1995
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pubmed:articleTitle |
The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis.
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pubmed:affiliation |
Department of Child Health, King's College Hospital Medical School, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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