rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
1996-3-21
|
pubmed:abstractText |
The effects of the partial pressure of oxygen (pO2) on antioxidant efficiency of beta-carotene in inhibiting 2,2'-azobis(2-amindinopropane) (AAPH)-induced lipid peroxidation are investigated in rat liver microsomal membranes. The rate of peroxyl radicals generated by thermolysis of AAPH at 37 degrees C is markedly higher at 150 than 760 mm Hg pO2. At 150 mm Hg Po2 beta-carotene acts as an antioxidant, inhibiting 2,2'-azobis(2-amidinopropane) 9AAPH0-induced Malonidaldehyde (MDA) formation. At 760 mm Hg Po2, it loses its antioxidant activity and shows a prooxidant effect, increasing lipid peroxidation products. alpha-Tocopherol prevents the prooxidant effect of beta-carotene in a dose-dependent manner. Our data provide the first evidence of a prooxidant effect of beta-carotene under 100% oxygen pressure in a biological membrane model and point out the existence of cooperative interactions between beta-carotene and alpha-tocopherol.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0891-5849
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
887-92
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8582664-Amidines,
pubmed-meshheading:8582664-Animals,
pubmed-meshheading:8582664-Antioxidants,
pubmed-meshheading:8582664-Carotenoids,
pubmed-meshheading:8582664-Drug Interactions,
pubmed-meshheading:8582664-Free Radicals,
pubmed-meshheading:8582664-Lipid Peroxidation,
pubmed-meshheading:8582664-Malondialdehyde,
pubmed-meshheading:8582664-Microsomes, Liver,
pubmed-meshheading:8582664-Oxygen,
pubmed-meshheading:8582664-Partial Pressure,
pubmed-meshheading:8582664-Rats,
pubmed-meshheading:8582664-Rats, Wistar,
pubmed-meshheading:8582664-Vitamin E,
pubmed-meshheading:8582664-beta Carotene
|
pubmed:year |
1995
|
pubmed:articleTitle |
Prooxidant activity of beta-carotene under 100% oxygen pressure in rat liver microsomes.
|
pubmed:affiliation |
Institute of General Pathology, Catholic University, Rome, Italy.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|