Linked Life Data

8581163

Source:http://linkedlifedata.com/resource/pubmed/id/8581163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-3-19
pubmed:abstractText
The Gram-positive bacterium Listeria monocytogenes can actively induce its own uptake by epithelial cells and fibroblasts through a surface-exposed 80 kDa protein, internalin (InIA), encoded by inIA. We studied the distribution and the DNA polymorphism of inIA sequences in a wide variety of wild strains of L. monocytogenes as compared to other Listeria species. This was done by PCR-amplifying inIA sequences encoding the fifteen repeats A and the three repeats B of InIA. inIA-repeated sequences were only found in L. monocytogenes. The amplified fragment of inIA encoding the repeats A displayed an AIuI DNA polymorphism which arises from point mutations. These results indicate that inIA required for cell invasion is specific to L. monocytogenes and that the intragenic repeats only exhibit a genetic heterogeneity due to point mutations and not to recombinations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1350-0872
pubmed:author
pubmed:issnType
Print
pubmed:volume
142 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-80
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The inlA gene required for cell invasion is conserved and specific to Listeria monocytogenes.
pubmed:affiliation
INSERM U.411, Faculté de Médecine Necker-Enfants Malades, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't