Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1996-3-18
|
| pubmed:abstractText |
The present report describes developmental, phenotypic and functional features of unconventional CD4+ TCR alpha beta lymphocytes. In C57BL/6 mice, the majority of liver lymphocytes expressing intermediate intensity of TCR alpha beta (TCR alpha beta int) are CD4+ NK1.1+ and express a highly restricted TCR V beta repertoire, dominated by V beta 8 with some contribution by V beta 7 and V beta 2. Although these cells express the CD4 co-receptor, they are present in H2-1 A beta (A beta)-/- gene disruption mutants but are markedly reduced in beta 2-microglobulin (beta 2m)-/- mutant mice and hence are beta 2m dependent. Thymocytes expressing the CD4+ NK1.1+ TCR alpha beta phenotype are also beta 2m contingent, suggesting that these two T lymphocyte populations are related. The CD4+ NK1.1+ TCR alpha beta lymphocytes in liver and thymus share several markers such as LFA-1+, CD44+, CD5+, LECAM-1- and IL-2R alpha-. The CD4+ NK1.1+ TCR alpha beta int liver lymphocytes were not detected in athymic nu/nu mice. We conclude that beta 2m expression is crucial for development of the CD4+ NK1.1+ TCR alpha beta int liver lymphocytes and that thymus plays a major role. CD4+ TCR alpha beta int liver lymphocytes were also identified in NK1.1- mouse strains, there lacking the NK1.1 marker. We assume that the NK1.1 molecule is a characteristic marker of the CD4+ TCR alpha beta int liver lymphocytes in NK1.1+ mouse strains, although its expression is not obligatory for their development. The liver lymphocytes from beta 2m+/-, but not from beta 2m-/-, mice are potent IL-4 producers in response to CD3 or TCR alpha beta engagement and the IL-4 production by liver lymphocytes was markedly reduced by treatment with anti-NK1.1 mAb. We conclude that the CD4+ NK1.1+ TCR alpha beta int liver lymphocytes are capable of producing IL-4 in response to TCR stimulation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Ly,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Klrb1c protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0953-8178
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1729-39
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:8580071-Animals,
pubmed-meshheading:8580071-Antigens,
pubmed-meshheading:8580071-Antigens, Ly,
pubmed-meshheading:8580071-Antigens, Surface,
pubmed-meshheading:8580071-CD4 Lymphocyte Count,
pubmed-meshheading:8580071-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8580071-Female,
pubmed-meshheading:8580071-H-2 Antigens,
pubmed-meshheading:8580071-Histocompatibility Antigens Class II,
pubmed-meshheading:8580071-Immunophenotyping,
pubmed-meshheading:8580071-Interleukin-4,
pubmed-meshheading:8580071-Killer Cells, Natural,
pubmed-meshheading:8580071-Lectins, C-Type,
pubmed-meshheading:8580071-Liver,
pubmed-meshheading:8580071-Male,
pubmed-meshheading:8580071-Mice,
pubmed-meshheading:8580071-Mice, Inbred Strains,
pubmed-meshheading:8580071-Mice, Mutant Strains,
pubmed-meshheading:8580071-Mice, Nude,
pubmed-meshheading:8580071-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:8580071-Protein Biosynthesis,
pubmed-meshheading:8580071-Proteins,
pubmed-meshheading:8580071-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8580071-Thymus Gland,
pubmed-meshheading:8580071-beta 2-Microglobulin
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
IL-4 producing CD4+ TCR alpha beta int liver lymphocytes: influence of thymus, beta 2-microglobulin and NK1.1 expression.
|
| pubmed:affiliation |
Department of Immunology, University of Ulm, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|