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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-3-11
|
| pubmed:abstractText |
Long-term treatment with angiotensin-converting enzyme (ACE) inhibitors has beneficial effects in patients with chronic aortic regurgitation by reducing left ventricular volumes and regurgitant fraction. Velocity-encoded cine magnetic resonance imaging can directly measure antegrade (forward stroke volume) and retrograde blood flow (regurgitant volume) in the ascending aorta. Velocity-encoded cine magnetic resonance imaging was used in 9 patients with moderate to severe aortic regurgitation (regurgitant fraction 49% +/- 17%) to measure regurgitant fraction, regurgitant volume, and forward stroke volume at baseline and 3 months after therapy with enalapril (mean dose 29 +/- 13 mg). Ten additional patients with aortic regurgitation without any drug therapy served as a control group. In the treatment group, systolic blood pressure slightly decreased from 132 +/- 20 mm Hg to 121 +/- 14 mm Hg (p = not significant), whereas diastolic blood pressure and heart rate (beats per minute) remained unchanged. Regurgitant fraction decreased in 6 patients (responders) from 49% +/- 19% to 39% +/- 20% (percentage change 24% +/- 14%, p = 0.002) and was unchanged in 3 patients (nonresponder, 49% +/- 19% vs 51% +/- 16%; p = not significant). In the responder group, forward stroke volume increased from 128 +/- 32 ml to 148 +/- 57 ml, whereas regurgitant volume remained unchanged (67 +/- 40 ml vs 65 +/- 51 ml). At baseline, the responder group had a significant higher total vascular resistance than the nonresponder group (998 +/- 538 dyne.sec.cm-5 vs 625 +/- 214 dyne.sec.cm-5; p < 0.05). With enalapril treatment, total vascular resistance in the responder group tended to decrease (891 +/- 576 dyne.sec.cm-5), but slightly increased in the nonresponder group (679 +/- 276 dyne.sec.cm-5). The control group showed no changes in regurgitant fraction, regurgitant volume, forward stroke volume, and total vascular resistance at follow-up.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
131
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
289-93
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8579023-Adult,
pubmed-meshheading:8579023-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:8579023-Aorta,
pubmed-meshheading:8579023-Aortic Valve Insufficiency,
pubmed-meshheading:8579023-Blood Flow Velocity,
pubmed-meshheading:8579023-Case-Control Studies,
pubmed-meshheading:8579023-Enalapril,
pubmed-meshheading:8579023-Feasibility Studies,
pubmed-meshheading:8579023-Follow-Up Studies,
pubmed-meshheading:8579023-Hemodynamics,
pubmed-meshheading:8579023-Humans,
pubmed-meshheading:8579023-Magnetic Resonance Imaging, Cine,
pubmed-meshheading:8579023-Reproducibility of Results
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Assessment of hemodynamic effects of angiotensin-converting enzyme inhibitor therapy in chronic aortic regurgitation by using velocity-encoded cine magnetic resonance imaging.
|
| pubmed:affiliation |
Department of Radiology, University of California, San Francisco, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|