Linked Life Data

8577874

Source:http://linkedlifedata.com/resource/pubmed/id/8577874

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-3-14
pubmed:abstractText
We tested the hypothesis that sensory and nonsensory factors associated with birth stimulate respiratory behavior in the fetal and newborn rat. Late gestation (Day 21) rat fetuses were externalized from the uterus with intact umbilical connections to the dam and exposed to stimuli normally associated with labor and delivery. Onset and maintenance of respiratory movements were monitored. In the first experiment, rat fetuses were exposed to either: (i) simulated uterine contractions; (ii) cooling (26 degrees C); (iii) umbilical cord occlusion; or (iv) air heated to intrauterine temperature (37.5 degrees C). Subjects were videotaped for 1 h, and respiratory movements counted during tape review. Fetuses in each group showed some respiratory behavior although compression significantly elevated respiratory rate compared to other experimental conditions. All subjects in each group were respiring after 1 h, except for pups that received umbilical cord occlusion. The 100% attrition rate of the cord occlusion-alone group was reversed by combining cord occlusion with compression, or with compression and cooling, but not by combining cord occlusion with cooling. Simulated birth pups (i.e., those exposed to compression, cooling and umbilical cord occlusion) and normal, vaginally delivered pups breathed at identical rates and showed a similar pattern of postpartum breathing. These results suggest that mechanical stimulation of the fetus associated with uterine contractions plays a critical role in the maintenance of continuous respiration at birth. Possible mechanisms for the facilitative effects of compression on perinatal breathing are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1035-41
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Simulated uterine contractions facilitate fetal and newborn respiratory behavior in rats.
pubmed:affiliation
Department of Psychology, Indiana University, Bloomington 47405, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.