Linked Life Data

8577403

Source:http://linkedlifedata.com/resource/pubmed/id/8577403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-3-13
pubmed:abstractText
Modulation of excitatory postsynaptic currents by histamine was examined using whole cell recording methods in the CA1 region of slices of rat hippocampus. Histamine affected the N-methyl-D-aspartate (NMDA) component of the synaptic current in a pH-dependent manner: at lowered pH (7.2) it enhanced the NMDA-mediated synaptic currents while at raised pH (7.6) it reduced them. At a pH of 7.4 there was no significant action of histamine. Histamine failed to alter the non-NMDA component of the synaptic current. These results indicate that histamine acts at a postsynaptic site to modulate NMDA mediated synaptic currents in a pH dependent manner. This mechanism may have important implications for the pathophysiology of shifts in extracellular pH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
pH-dependent modulation of N-methyl-D-aspartate receptor-mediated synaptic currents by histamine in rat hippocampus in vitro.
pubmed:affiliation
Physiologisches Institut II, Heinrich-Heine-Universität, Düsseldorf, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't