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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1996-3-13
|
| pubmed:abstractText |
15 patients with predominantly alcoholtoxic liver cirrhosis (mean age 50 years; 8 men and 7 women) were treated by the technically successful implantation of a transjugular portosystemic stent-shunt (TIPS) within a period of 1 year. The indications for TIPS implantation were the following: gastroesophageal bleedings in 12 cases (10 patients with recurrent variceal bleeding including 2 emergency cases with severe bleeding resistant to conventional therapy and 2 patients with exclusively gastral bleeding due to severe hypertensive gastropathy) and ascites resistant to conventional therapy in 3 cases. Portovenous pressure could be effectively reduced by mean of 37%. Within a mean observation period of 8 months 13 patients including the emergency cases remained without recurrent bleeding. Duplexsonography showed patent stents. 1 patient suffered from an early recurrent bleeding due to occlusion of the stent-shunt. The estimation of liver function according to the Child-Pugh-classification showed only minor changes. Before TIPS 9 patients were in class A, 4 in B, 2 in C; after TIPS 8 patients in A, 5 in B and 2 in C. Ascites resolved completely. Following TIPS all patients appeared to abstain from alcohol. After TIPS 5 from 14 surviving patients (36%) developed clinically manifest encephalopathy within the first 4-8 weeks (2 patients with previous episodes of encephalopathy, 2 other patients after withdrawal of lactulose). By enhanced conservative treatment (lactulose, paromomycine and protein restriction) encephalopathy could be overcome. 8 from 11 surviving patients investigated displayed characteristic MRI changes with an increased signal intensity in the basal ganglia (T1 weighted images). According to our preliminary results TIPS represents a new successful interventional regimen for the treatment of portal hypertension in selected cases.
|
| pubmed:commentsCorrections | |
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0300-8622
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
264-6, 269-70
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8577216-Adult,
pubmed-meshheading:8577216-Aged,
pubmed-meshheading:8577216-Blood Flow Velocity,
pubmed-meshheading:8577216-Catheters, Indwelling,
pubmed-meshheading:8577216-Esophageal and Gastric Varices,
pubmed-meshheading:8577216-Female,
pubmed-meshheading:8577216-Follow-Up Studies,
pubmed-meshheading:8577216-Gastrointestinal Hemorrhage,
pubmed-meshheading:8577216-Hepatic Encephalopathy,
pubmed-meshheading:8577216-Humans,
pubmed-meshheading:8577216-Jugular Veins,
pubmed-meshheading:8577216-Liver Function Tests,
pubmed-meshheading:8577216-Male,
pubmed-meshheading:8577216-Middle Aged,
pubmed-meshheading:8577216-Portasystemic Shunt, Surgical,
pubmed-meshheading:8577216-Recurrence,
pubmed-meshheading:8577216-Stents,
pubmed-meshheading:8577216-Survival Rate,
pubmed-meshheading:8577216-Treatment Outcome,
pubmed-meshheading:8577216-Ultrasonography, Doppler, Color
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
[Initial clinical experiences with TIPS (transjugular intrahepatic portasystemic stent-shunt)].
|
| pubmed:affiliation |
Medizinische Klinik, Georg-August-Universität, Göttingen.
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Case Reports
|