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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-3-12
|
| pubmed:abstractText |
In order to study the prevalence of hepatitis E virus (HEV) infection in developed countries, IgG and IgM anti-HEV were determined in serum samples from 382 patients with acute viral hepatitis (244 hepatitis A, 48 hepatitis B and/or D, and 90 non-A, non-B, non-C hepatitis), 76 healthy subjects, 55 hemophiliacs and 50 patients on hemodialysis. IgG anti-HEV antibodies were detected and confirmed by a synthetic peptide-based EIA in 5 (5.6%) non-A, non-B, non-C acute hepatitis, in 3 (6.5%) B and D acute hepatitis, in 10 (4%) acute A hepatitis, in 3 (5.5%) of 54 healthy adults in none of the hemophiliacs and in 3 (6%) patients on hemodialysis. IgM anti-HEV antibodies were only detected in two cases of acute hepatitis B and/or D. Analysis of serial serum samples demonstrated IgG anti-HEV seroconversion in 3 of the 18 confirmed cases; one of them was also positive for IgM anti-HEV. All 3 acute anti-HEV-positive hepatitis cases occurred in adults, were community-acquired (two of them were intravenous drug addicts) and had a self-limited course. These results demonstrate that HEV is a minor cause of acute hepatitis in Spain. A similar low rate of IgG anti-HEV antibodies was detected in patients with different diseases, suggesting that HEV has a very low epidemiological impact. An apparent association of HEV infection with hepatitis B and D suggests a possible parenteral transmission of a mainly enteral pathogen.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0166-0934
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
49-54
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8576308-Acute Disease,
pubmed-meshheading:8576308-Adolescent,
pubmed-meshheading:8576308-Adult,
pubmed-meshheading:8576308-Aged,
pubmed-meshheading:8576308-Aged, 80 and over,
pubmed-meshheading:8576308-Antibodies, Viral,
pubmed-meshheading:8576308-Child,
pubmed-meshheading:8576308-Child, Preschool,
pubmed-meshheading:8576308-Female,
pubmed-meshheading:8576308-Hemophilia A,
pubmed-meshheading:8576308-Hepatitis E,
pubmed-meshheading:8576308-Hepatitis E virus,
pubmed-meshheading:8576308-Humans,
pubmed-meshheading:8576308-Infant,
pubmed-meshheading:8576308-Longitudinal Studies,
pubmed-meshheading:8576308-Male,
pubmed-meshheading:8576308-Middle Aged,
pubmed-meshheading:8576308-Prevalence,
pubmed-meshheading:8576308-Renal Dialysis,
pubmed-meshheading:8576308-Retrospective Studies,
pubmed-meshheading:8576308-Spain
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Hepatitis E virus infection in acute hepatitis in Spain.
|
| pubmed:affiliation |
Department of Medicine, Hospital General Universitario Vall d'Hebron, Barcelona, Spain.
|
| pubmed:publicationType |
Journal Article
|