Linked Life Data

8575517

Source:http://linkedlifedata.com/resource/pubmed/id/8575517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-3-14
pubmed:abstractText
In different animal species, microinjections of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the nucleus tractus solitarii failed to alter arterial blood pressure and sympathetic nerve activity; however, the cardiovascular effects (hypotension, bradycardia, reduction in sympathetic nerve activity) of intravenous administration of 8-OH-DPAT were significantly reduced after blockade of the nucleus tractus solitarii by kainic acid as well as after blockade of the lateral tegmental field by kainic acid. The aim of the present study was to clarify these conflicting results. In the anesthetized cat, inhibition of neurotransmission in the nucleus tractus solitarii by bilateral microinjections of either muscimol (1 nmol in 50 nl) or kynurenic acid (2.5 nmol in 50 nl) suppressed the baroreceptor reflex and abolished the synchronism between the renal sympathetic bursts; however, these procedures did not alter the dose-related hypotension, bradycardia and sympatho-inhibition elicited by cumulative doses of 8-OH-DPAT (1-30 micrograms/kg i.v.). Moreover complete electrolytic destruction of the nucleus tractus solitarii, assessed by a complete loss of the baroreceptor reflex and the cardiac-related bursts of the sympathetic nerves, failed to alter the inhibitory effects of i.v. 8-OH-DPAT. Bilateral microinjections of muscimol into the lateral tegmental field induced a decrease of mean arterial blood pressure, heart rate and renal nerve activity (by respectively -35 +/- 13 mm Hg, -30 +/- 16 beats/min and -53 +/- 14%) and greatly reduced the effects of subsequent i.v. administration of 8-OH-DPAT. The present data indicate that the nucleus tractus solitarii does not play a dominant role in the central action of 8-OH-DPAT whereas they confirm our previous results showing that the lateral tegmental field is involved in this action and in the mecanisms regulating sympathetic tone. The results also suggest that kainic acid lesions are not restricted to the region in which the neurotoxic agent is injected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
285
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-304
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:8575517-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:8575517-Animals, pubmed-meshheading:8575517-Blood Pressure, pubmed-meshheading:8575517-Cats, pubmed-meshheading:8575517-Dose-Response Relationship, Drug, pubmed-meshheading:8575517-Excitatory Amino Acid Agonists, pubmed-meshheading:8575517-Excitatory Amino Acid Antagonists, pubmed-meshheading:8575517-Female, pubmed-meshheading:8575517-GABA Agonists, pubmed-meshheading:8575517-Heart Rate, pubmed-meshheading:8575517-Kainic Acid, pubmed-meshheading:8575517-Kynurenic Acid, pubmed-meshheading:8575517-Male, pubmed-meshheading:8575517-Microinjections, pubmed-meshheading:8575517-Muscimol, pubmed-meshheading:8575517-Serotonin Receptor Agonists, pubmed-meshheading:8575517-Solitary Nucleus, pubmed-meshheading:8575517-Sympatholytics, pubmed-meshheading:8575517-Synaptic Transmission, pubmed-meshheading:8575517-Tegmentum Mesencephali
pubmed:year
1995
pubmed:articleTitle
Evidence against the involvement of the nucleus tractus solitarii in the sympatholytic effect of 8-hydroxy-2-(di-n-propylamino)tetralin in the cat.
pubmed:affiliation
Servier Research Institute, Department of Angiology, Suresnes, France.
pubmed:publicationType
Journal Article