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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1996-3-14
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pubmed:abstractText |
Twenty-eight infants with postmenstrual ages (PMA) in the range of 32-80 weeks were investigated. Twenty were newborn; among these the observed birth weight divided by the expected weight ranged from 0.31 to 1.1. Axial magnetic resonance images were recorded with a triple spin-echo sequence and the volumes were determined by encircling each structure of interest on every slice. Segmentation into grey matter, white matter and CSF was done by semi-automatic discriminant analysis. Growth charts for the cerebrum, cerebellum, corpora striata, thalami, ventricles, and grey and white matter are provided for infants with appropriate birth weight. The striatal (P = 0.02) and thalamic (P < 0.001) percentage of the hemispheric volume decreased with age, whereas the ratio of grey matter to white matter (G/W-ratio) increased (P = 0.01). In the neonatal patients, brain volumes were independently associated with both PMA and the degree of growth retardation. It was calculated that the hemispheric volume was reduced by from 16% to 23% if the total bodyweight was reduced by 40%. The G/W-ratio was found to be independently associated with the PMA (P < 0.05) and the degree of IUGR (P < 0.1) suggesting that fetal growth retardation reduces grey matter volume more than white matter.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0378-3782
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-29
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8575348-Birth Weight,
pubmed-meshheading:8575348-Brain,
pubmed-meshheading:8575348-Cerebellum,
pubmed-meshheading:8575348-Cerebral Ventricles,
pubmed-meshheading:8575348-Corpus Striatum,
pubmed-meshheading:8575348-Fetal Growth Retardation,
pubmed-meshheading:8575348-Gestational Age,
pubmed-meshheading:8575348-Humans,
pubmed-meshheading:8575348-Infant, Newborn,
pubmed-meshheading:8575348-Linear Models,
pubmed-meshheading:8575348-Magnetic Resonance Imaging,
pubmed-meshheading:8575348-Observer Variation,
pubmed-meshheading:8575348-Reproducibility of Results,
pubmed-meshheading:8575348-Thalamus
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pubmed:year |
1995
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pubmed:articleTitle |
Volumetric analysis of the normal infant brain and in intrauterine growth retardation.
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pubmed:affiliation |
Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, Denmark.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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