| pubmed-article:8575310 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C2266214 | lld:lifeskim |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:8575310 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:8575310 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8575310 | pubmed:dateCreated | 1996-3-11 | lld:pubmed |
| pubmed-article:8575310 | pubmed:abstractText | The tissue polarity genes in Drosophila are required to coordinate cell polarity within the plane of the epidermis. Evidence to date suggests that these genes may encode components of a novel signal transduction pathway. Three of the genes, frizzled (fz), dishevelled (dsh), and prickle (pk) share a similar tissue polarity phenotype, suggesting that they function together in a single process. dsh is also known to function as a mediator of wingless (wg) signaling in a variety of developmental patterning processes in the fly. In this study, we make use of a fz transgene and a hypomorphic fz allele as genetic tools in an attempt to order these genes in a genetic hierarchy. Our results argue that dsh encodes a dosage sensitive component required for fz function and that it likely acts downstream of fz in the generation of tissue polarity. Our findings suggest that dsh may have a general role in signal transduction, perhaps as a component of a receptor complex. | lld:pubmed |
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| pubmed-article:8575310 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8575310 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8575310 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8575310 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8575310 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8575310 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:8575310 | pubmed:author | pubmed-author:AdlerP NPN | lld:pubmed |
| pubmed-article:8575310 | pubmed:author | pubmed-author:WongL LLL | lld:pubmed |
| pubmed-article:8575310 | pubmed:author | pubmed-author:KrasnowR ERE | lld:pubmed |
| pubmed-article:8575310 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8575310 | pubmed:volume | 121 | lld:pubmed |
| pubmed-article:8575310 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8575310 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8575310 | pubmed:pagination | 4095-102 | lld:pubmed |
| pubmed-article:8575310 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8575310 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8575310 | pubmed:articleTitle | Dishevelled is a component of the frizzled signaling pathway in Drosophila. | lld:pubmed |
| pubmed-article:8575310 | pubmed:affiliation | Biology Department, University of Virginia, Charlottesville 22903, USA. | lld:pubmed |
| pubmed-article:8575310 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8575310 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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