Linked Life Data

8574606

Source:http://linkedlifedata.com/resource/pubmed/id/8574606

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-3-8
pubmed:abstractText
Patients with acute renal failure are commonly treated by continuous renal replacement therapies. To understand drug disposition in multiple organ failure patients, the pharmacokinetics of 18 drugs were evaluated in 243 patients. Continuous hemofiltration served as a model for constant elimination rates. In addition, the elimination of drugs was investigated during extracorporeal lung support. The dosage of 11 of 15 drugs had to be reduced as a result of these kinetic studies. Wide variability in volumes of distribution, clearances, and the extrarenal fractions of elimination were detected. There was a close correlation of the latter with Acute Physiology and Chronic Health Evaluation II scores of illness severity. A new algorithm was developed for primary estimates of drug dosage during hemofiltration and other organ support systems. Two in vitro studies confirmed the clinical results on drug sieving and provided important information on adsorption to membranes. A clinical validation study of the algorithm improved drug dosage. A simplified therapeutic drug monitoring approach is given.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1063-7389
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
748-59
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Drug administration in critically ill patients with acute renal failure.
pubmed:affiliation
Abteilung für Anästhesie und Intensivtherapie, Klinikum der Philipps-Universität Marburg, Germany.
pubmed:publicationType
Journal Article, Review