Linked Life Data

8572612

Source:http://linkedlifedata.com/resource/pubmed/id/8572612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5B
pubmed:dateCreated
1996-3-1
pubmed:abstractText
Topoisomerases are widely detected in rapidly proliferating cancer cells. Many anti-topoisomerase agents are utilized for cancer chemotherapy. Testicular cancers are highly chemotherapy sensitive, however, 10% of them are refractory to the standard regimen. To investigate the topoisomerase activities in human testicular neoplasms, we examined the activity of topoisomerase I (TopoI) and topoisomerase II (TopoII) in 29 testicular tumors. TopoI activity was observed irrespective of pathological types of the tumor (21/29). TopoII was detected in seminoma and teratocarcinoma (5/29). In our experience, seminoma was relatively sensitive to chemotherapy including anti-TopoII agents. Our results suggest that Topol inhibitors could be more effective against seminoma as well as the other types of testicular tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2117-20
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
A study of topoisomerase activity in human testicular cancers.
pubmed:affiliation
Department of Urology, School of Medicine, Yokohama City University, Japan.
pubmed:publicationType
Journal Article