Linked Life Data

8570692

Source:http://linkedlifedata.com/resource/pubmed/id/8570692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1333
pubmed:dateCreated
1996-3-1
pubmed:abstractText
The cytochrome P450 steroid hydroxylases exhibit tissue-specific and developmentally regulated gene expression. Recent studies showed that the orphan nuclear receptor steroidogenic factor 1 (SF-1) plays a key role in their gene regulation. In mouse embryos, SF-1 expression began at the inception of adrenal and gonadal development, suggesting that SF-1 plays a key role in the steroidogenic cell differentiation. SF-1 was also expressed in the developing pituitary gland and diencephalon, which raised the possibility that it also has additional roles in endocrine development. To examine the role of SF-1 in intact mice, we disrupted the gene encoding SF-1 by homologous recombination in embryonic stem cells; this approach ultimately permitted us to generate SF-1 knockout mice in which the gene encoding SF-1 was inactivated. These studies revealed essential roles of SF-1 in endocrine development that included adrenal and gonadal development, expression of several markers of pituitary gonadotropes, and formation of the ventromedial hypothalamic (VMH) nucleus. These results indicate that SF-1 acts at multiple levels of the reproductive axis to maintain reproductive competence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0962-8436
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
350
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-83
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The cell-specific nuclear receptor steroidogenic factor 1 plays multiple roles in reproductive function.
pubmed:affiliation
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't