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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1996-3-1
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pubmed:abstractText |
We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1249840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1328198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1396586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-14731645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1518076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1631557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1641027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1715687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-17810339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1784189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-1956407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-2025413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-2357959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-2376592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-3313058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-3775366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-4079800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-5551392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-7560881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-7617293,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-7826378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-7922031,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8570652-875032
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
878-83
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:8570652-Base Sequence,
pubmed-meshheading:8570652-Bone Morphogenetic Protein 7,
pubmed-meshheading:8570652-Bone Morphogenetic Proteins,
pubmed-meshheading:8570652-Crystallography,
pubmed-meshheading:8570652-Humans,
pubmed-meshheading:8570652-Models, Molecular,
pubmed-meshheading:8570652-Molecular Sequence Data,
pubmed-meshheading:8570652-Protein Structure, Secondary,
pubmed-meshheading:8570652-Protein Structure, Tertiary,
pubmed-meshheading:8570652-Proteins,
pubmed-meshheading:8570652-Recombinant Proteins,
pubmed-meshheading:8570652-Transforming Growth Factor beta
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pubmed:year |
1996
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pubmed:articleTitle |
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily.
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pubmed:affiliation |
Rosenstiel Basic Medical Research Center, Brandeis University, Waltham, MA 02254, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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